Our research is focused on using stem cells to better understand how genetic disorders and prematurity affect a child’s development over the course of his or her lifetime and to ultimately develop new treatment strategies.

We aim to apply novel cell imaging techniques, genomics approaches and computational biology to generate novel models of human disease and development using induced pluripotent stem cells.

Paul Lerou, our PI, recently became Chief of Neonatology and Newborn Medicine at MassGeneral Hospital for Children.

Until our lab is ready for the big move to MGH, it remains at Brigham and Women’s Hospital in the Department of Pediatric Newborn Medicine and the Division of Genetics (Department of Medicine).


  • Testimonial

    Paul Lerou, MD


    About Paul Lerou, MD

    Paul graduated from Jefferson Medical College and did his residency and chief residency at Boston Children’s Hospital, followed by fellowship in the Harvard Neonatal-Perinatal Fellowship Training Program. He did his post-doctoral research in the George Daley Laboratory at Boston Children’s Hospital.

    He is currently a neonatologist at Massachusetts General Hospital, where he serves as Division Chief of Neonatology and Newborn Medicine for MassGeneral Hospital for Children. He is an Assistant Professor of Pediatrics at Harvard Medical School.

  • Testimonial

    Junjie Lu, PhD

    Post Doc / Senior Scientist

    About Junjie Lu, PhD

    Junjie obtained his PhD in 2011 at the Florida State University. His thesis work done in David Gilbert lab was focused on epigenetic regulation of genome replication. He has completed a project on copy number variation distribution during reprogramming and is now studying on the role of higher-order chromatin structure in regulation of alternative splicing using ATM deficient iPS cells as an experimental platform.

  • Testimonial

    Jeanne Carroll, MD

    Post Doc

    About Jeanne Carroll, MD

    Jeanne is a Harvard Neonatal-Perinatal Medicine Fellow. She earned her MD degree at the University of Virginia and completed pediatric residency at University of California, San Diego.

  • Testimonial

    Ruggero Spadafora, MD

    About Ruggero Spadafora, MD

    Ruggero is from Italy where he attended medical school and completed pediatric residency at the University of Pavia. After a 3-year post-doctoral fellowship in Prof. D. Ferriero’s lab in neurolobiology at UCSF, he completed the Harvard Neonatal Perinatal Fellowship in 2013. He is currently a staff physician at BWH and instructor at HMS.

  • Testimonial

    Bryan Gorman, PhD

    PhD Candidate; Medical Engineering and Medical Physics; MIT - HST

    About Bryan Gorman, PhD

    Bryan did his undergraduate studies at Vanderbilt University in biomedical engineering and mathematics (B.E., M.S.). He has developed a Multi-scale imaging and informatics pipeline for in situ pluripotent stem cell analysis. This tool is essential for advanced tissue analysis because it enables one to accurately measure cellular relationships over multiple length scales and resolutions of tissue morphology. He plans to use this tool to perform analysis of heterogeneity at the transcriptional level using single molecule fluorescent in situ hybridization (smFISH), and combining such data with information from live-cell imaging prior to fixation — thus establishing a framework for generation of high-quality data for modeling cellular decision-making in heterogeneous tissues. He earned his PhD in Medical Engineering and Medical Physics at MIT in the fall of 2014.

  • Testimonial

    Junning Wang

    Research Assistant II

    About Junning Wang

    Junning has been a research assistant at BWH since 2009 working for Professor Raju Kucherlapati and prior to that was a research fellow for 8 years. Her experience ranges from gene modification to mouse endoscopy!

  • Testimonial

    Sean McManus

    Research Assistant II

    About Sean McManus

    Sean earned his BS at Villanova University where he worked as a research assistant in a Biothermal Sciences Laboratory using high-speed video cryomicroscopy to study how cooling rates affect intracellular ice formation and cell viability. Since graduation he has been a research assistant in oncology clinical research at Millennium Pharmaceutical in Cambridge. He is enrolled in the Master of Science in Medical Sciences at Boston University School of Medicine and plans to go to medical school in 2016.


77 Avenue Louis Pasteur
Harvard Institutes of Medicine, Rm 823
Boston, MA, 02115


tel: (617) 525 5072
fax: (617) 525 5048